منابع مشابه
Islet biology
Loss or dysfunction of insulin-producing beta cells underlies the development and progression of diabetes. Thus, world-wide efforts are on the way to either trigger endogenous beta cell regeneration or replenish lost beta cell mass by exogenous sources, e.g. human islets or stem cell-derived islet cells. Although remarkable progress has been made, as of today functionally mature beta cells cann...
متن کاملIslet Biology/Insulin Secretion
duces proinflammatory lipids that exacerbate β cell dysfunction and death. Inhibition of 12/15-LOX thereby provides a potential therapeutic approach to prevent glycemic deterioration in T1D, but to date no specific inhibitors have been tested T1D. Here we assessed the efficacy and mechanism of a novel and specific 12/15-LOX inhibitor, ML351. Using cultured β cells in vitro, ML351 exhibited no a...
متن کاملIslet Cell Biology, Regeneration, and Transplantation
1 Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA 2Alpha Hospital and Research Center, Institute of Diabetes and Endocrinology, Madurai, Tamilnadu 625009, India 3Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA 4Baylor Simmons Transplant Institute, ...
متن کاملZinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes
About 20 chemical elements are nutritionally essential for humans with defined molecular functions. Several essential and nonessential biometals are either functional nutrients with antidiabetic actions or can be diabetogenic. A key question remains whether changes in the metabolism of biometals and biominerals are a consequence of diabetes or are involved in its etiology. Exploration of the ro...
متن کاملIntroducing a New Experimental Islet Transplantation Model using Biomimetic Hydrogel and a Simple High Yield Islet Isolation Technique
Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functi...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2017
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2017.06.005